Download e-book for kindle: Tubulin-Binding Agents: Synthetic, Structural and by Teresa Carlomagno

By Teresa Carlomagno

ISBN-10: 3540690360

ISBN-13: 9783540690368

ISBN-10: 3642435947

ISBN-13: 9783642435942

experiences. The SAR facts are mentioned in mild of the structural info on hand for every agent. the second one bankruptcy specializes in the entire synthesis of the marine sponge-derived polyketide discodermolide. A finished survey of the unreal chemistry efforts of a number of teams over a 14-year interval is equipped including a compa- son of the various ways. The 3rd bankruptcy describes a accomplished research of the mechanisms of task of microtubules stabilizing medications. Thermodynamic, kinetic, structural and fu- tional info on microtubules stabilizing medications are mentioned in an interdisciplinary demeanour to generate a “time-resolved” photo of the interplay of the medicine with diversified tubulin varieties. The fourth and 5th chapters overview the efforts and achievements made within the characterization of the constitution of the complexes of tubulin with microtubules stabilizing brokers by way of NMR (Chapter four) and EM (Chapter 5). in particular obvious is the discrepancy of the implications bought for epothilones, the place the 2 strategies carry extensively various constructions of the certain drug. either NMR and EM types are, despite the fact that, capable of clarify a constant set of SAR facts. The authors of the 2 chapters speak about significantly the benefits and obstacles of every methodology.

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Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights (Topics in Current Chemistry) by Teresa Carlomagno

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